Posts

Forward

 This book will explore the concepts associated with human longevity and life extension. Inclusive of the same will be chapters on the physical,medical, biochemical, genetic,environmental , emotional,cultural, economic, and other factors associated with aging and their known causes. Known means to appropriately address the causes of aging, halt aging, and reverse the again process, both theoretical and actual, will be explored in detail with the goal of providing the reader with the means to successfully implement the same. Chapter one will explore and define the basics of human ageing and the concepts associated with the same including the effects of aging on the human being, basic statistics associated with the same, longevity, death, healthy ageing and life extension. Chapter two will examine ageing from a molecular level for the purpose of understanding what interventions individuals might take to delay the ageing process and promote healthy ageing. Chapter three will identify life

Chapter 1. : Human Aging, Longevity, Death and Life Extension Defined

 Human ageing (sometimes spelled aging) is defined as: "1. The process of becoming older or more mature---4. (gerontology) Becoming senescent; accumulating damage to macromolecules,cells, tissues and organs with the passage of time." 1. Two other definitions of human ageing: "Ageing, also spelled aging, is the process of becoming older." 2. " In humans, ageing represents the accumulation of changes in a human being over time, encompassing physical, psychological, and social change.---Ageing is among the greatest known risk factors for most human diseases; of roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes." 3. "Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative

Chapter 2. : Aging at the Molecular and Cellular Level

 What are the hallmarks of aging at the molecular and cellular level? Long quote: "This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contributions to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging, with minimal side effects." 1. In summary of the aforementioned, the 9 hallmarks of aging at the molecular and cellular level are: 1. Stem Cell Exhaustion; 2. Altered inter-cellular communication; 3. Genomic Instability; 4. Telomere attrition; 5. Epigenetic alterations; 6.

Chapter 3. : Life Style and Life Extension

 Long Quote "Aging is defined as the progressive decline in physiological functions which leads to increased vulnerability to diseases and death [1]. This is a universal process underlying by many mechanisms and different pathways, whose burden rises to three different phenotypes: normal aging, accelerated aging and successful aging  2]. Despite variability among definitions, “successful aging” is as a multidimensional process encompassing major chronic diseases, major impairments in cognitive, in physical function and sustained engagement in social and productive activities [2, 3]. However, reaching old age in good health is not just a “fate effect” but the result of a complex interweaving between environmental and genetic factors [ 4]. Studies conducted in twins have estimated that approximately 20-30% of an individual's lifespan is related to genetics, while the rest is due to individual behaviors and environmental factors [ 5, 6]. In this contest, nutrition and lifestyle a

Chapter 4.: Dietary and Medical Interventions for Life Extension

 Protecting telomere erosion promotes: 1. Health; 2. Prevents diseases; and, Prevents premature aging. 1. Water is the basic and most vital nutrient .2. As water purity increases, the factors responsible for "Aging at the Molecular and Cellular" levels are proportionately ameliorated. The factors involved in life extension, telomerase activity, and telomere shortening and water quality are complex. Water serves as the body's transportation system, removes wastes and toxins, affects the digestive system, participates the the body's biochemical reactions and 99% of all of the body's chemical reactions. 3. As stated before, pure clean water is the fundamental dietary and medical intervention for telomere health and life extension. Water purification, over and above the purity of water coming out of the tap, is fundamental to diminishing the shortening of telomeres over time. This mandates the use of water filters or other means to increase the purity of water coming